DENS - Clinical Dental Therapeutics Lecture 4 Pharmacology of Metronidazole and Antifungal Agents
نویسنده
چکیده
II. The occurrence of modified penicillin-binding sites Modified PBPs have a lower affinity for β-lactam antibiotics, requiring clinically unattainable concentrations of the drug to effect its bactericidal activity Example: penicillin resistance in Streptococcus pneumoniae (pneumococcus) is caused by altered PBPs I. Production of β-lactamases This family of enzymes can inactivate penicillins by hydrolyzing the β-lactam ring The production of β-lactamases is considered the principal cause of bacterial resistance to b-lactam antibiotics Examples of bacteria that produce β-lactamases are staphylococcus aureus and many strains of H. influenzae, Neisseria, and Pseudomonas
منابع مشابه
Antimicrobial Activity of Ketoconazole and Fluconazole against Metronidazole Resistance Strains of Helicobacter pylori: an In Vitro Study
Resistance to drug such as metronidazole is one the commonest causes of treatment failure while eradicating Helicobacter pylori . Considering the safety of ketoconazole and fluconazole and their inhibitory activity on biosynthesis of fatty acids from cholesterol in cell membrane of H.pylori , the idea of their efficacy against H.pylori is raising . The aim of this study is to evaluate suscep...
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